By E. J. Corey
Molecules and medication presents, for the 1st time ever, a very built-in examine chemistry, biology, drug discovery, and medication. It delves into the invention, program, and mode of motion of a couple of hundred of the main major molecules in use in sleek drugs. beginning sections of the e-book supply a distinct, transparent, and concise advent, which allows readers to appreciate chemical formulation.
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Jr. • . ~ &;,.. ,~ : ... JI':' .. Z' • .. J ". '. ;~ . . . ~ " .. '"lI·~ (. . , ,,~ . • l ". ' • ) MOLECULES AND MEDICINE PROTEINS AND THREE·DIMENSIONAL PROTEIN STRUCTURES Introduction Proteins are very large molecules formed by the joining of many a-amino acid subunits through amide linkages. A subsection of a protein chain can be represented in a general and highly simplified way by a two dimensional line drawing (Figure 1). ~yt~~~yt~~~) .. R' 0 R' 0 R' Figure 1. Portion of a protein/polypeptide chain .
32 A). ~J ~ o oe l OH H2N ~ N ~ ~ / H2N ~ N0~~OH H, N - 0 Ala-Gly-Phe (alanyl-glycinyl-phenylalanine) 0 y glycylglycine R Figure 9. Structures of a generic tripeptide and of the specific tripeptide Ala-Gly-Phe. 32 A efr", : , ,.. 46 A (free rotation) (free rotation) The sequence of the individual amino acids in a polypeptide or protein, the primary structure, is critical to its preferred three dimensional shape and properties. It is the very large number of possible sequences that enables the existence of an unima~inably large number of possible proteins (100 0 for a 100 amino acid protein).
2005, 353, 1711-1723; 2. Br. J. Pharmacal. 2006 , 148, 245-254 ; 3. Ann. N. Y. Acad. Sci. 2006, 1088, 396-409; Refs. p. 81 45 ~ MOLECULES AND MEDICINE METHOTREXATE (TREXALLm) Structural Formula Ball-and-Stick Model Space-filling Model i HJ ~ N~" H N" 0 :~"'rOH h N, H'"hIN 0LOH. I N-y-N NH, • = Carbon = Hydrogen • = Oxygen • = Nitrogen Year of discovery: 1948 (Lederle); Year of introduction : 1953; Drug category: Antimeta bolite/disease-modifying anti-inflammatory agenUimmunosuppressant; Main uses: For treatment of inflammation associated with autoimmunity (rheumatoid arthritis, Crohn's disease and psoriasis) ; Other brand names: Rheumatrex; Re/ated drugs: Trimetrexate (Neutrexin) , Pemetrexed (Alimta).