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By Claire Dulieu, Denis Poncelet, Ronald J. Neufeld (auth.), Willem M. Kühtreiber PhD, Robert P. Lanza MD, William L. Chick MD (eds.)

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It is important to note that in the operation of a bioreactor, the gas to bulk liquid oxygen transfer is the only resistance that can be controlled. Varying the aeration rate will affect the gas to liquid oxygen transfer, which in turn will affect the transfer of oxygen from the bulk liquid to the cell. Researchers have, therefore, focused on measuring the mass transfer coefficient kp, under various operating conditions, for the purpose of developing useful correlations that may be employed as scale-up criteria for animal cell bioreactors.

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L35: 198. Smidsrod 0, Haug A, Lian B. 1972. Acta Chern. Scand. 26:71. Smidsrod O. 1974. Faraday Discuss. Chern. Soc. 57: 263. Sonomoto K, Hoq MM, Tanaka A, Fukui S. 1981. 1. Ferment. Technol. 59: 465. Stevenson WTK, Sefton MV. 1. Appl. Polym. Sci. 32: 1541. Stevenson WTK, Sefton MV. 1993. ), Boca Raton: CRC Press, p. 143. Sun AM and 0' Shea GM. 1985. Methods Enzymol. 137: 575. Sun YM, Chang CC, Huang WF, Liang HC. 1997. J. Control. Release 47: 247. Tampion J, Tampion MD. 1987. Immobilized cells: principles and applications, Cambridge: Cambridge University Press.

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