Download Cardiac Energy Metabolism in Health and Disease by Gary D. Lopaschuk, Naranjan S. Dhalla PDF

By Gary D. Lopaschuk, Naranjan S. Dhalla

The center has a truly excessive strength call for yet little or no strength reserves. to be able to maintain contractile functionality, the center has to repeatedly produce a large number of ATP. the center makes use of loose fatty acids quite often and carbohydrates to a point as substrates for making strength and any swap during this power offer can heavily compromise cardiac functionality. It has emerged that adjustments in cardiac strength metabolism are a massive contributor to the improvement of a couple of diverse different types of center disorder. it's also referred to now that optimizing power metabolism within the middle is a conceivable and critical method of treating quite a few different types of middle disease.

Cardiac power Metabolism in overall healthiness and Disease describes the study advances which have been made in realizing what controls cardiac power metabolism at molecular, transcriptional and physiological degrees. It additionally describes how adjustments in power metabolism give a contribution to the advance of middle disorder and the way optimization of strength metabolism can be utilized to regard center disorder. the themes lined contain a dialogue of the consequences of myocardial ischemia, diabetes, weight problems, hypertrophy, center failure, and genetic issues of mitochondrial oxidative metabolism on cardiac energetics. The therapy of middle ailment via optimizing power metabolism is additionally mentioned, consisting of expanding total strength creation in addition to expanding the potency of strength creation and switching power substrate choice of the center. This e-book might be a priceless resource of knowledge to graduate scholars, postdoctoral fellows, and investigators within the box of experimental cardiology in addition to biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and different wellbeing and fitness professionals.

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Additional info for Cardiac Energy Metabolism in Health and Disease

Sample text

In addition heart synthesizes very little cholesterol [15]. Perhaps, as shown in isolated perfused hearts [9], the robust metabolism of TG-rich lipoproteins, as they circulate through the heart, is sufficient to provide cholesterol for the myocardium. Lipoproteins and Cardiac Lipids 6 19 HDL HDL biosynthesis takes place in the liver and small intestine. ApoA-I is secreted by the liver and interacts with hepatic ABCA1 transporter (Fig. 2). ApoA-I is then lipidated with phospholipids and cholesterol and forms discoidal HDL particles.

Fielding CJ (1978) Metabolism of cholesterol-rich chylomicroms mechanism of binding and uptake of cholesteryl esters by the vascular bed of the perfused rat heart. J Clin Invest 62: 141–151 10. Mardy K, Belke DD, Severson DL (2001) Chylomicron metabolism by the isolated perfused mouse heart. Am J Physiol Endocrinol Metab 281:E357–E364 11. Ginsberg HN, Fisher EA (2009) The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism. J Lipid Res 50:S162–S166 12. Ota T, Gayet C, Ginsberg HN (2008) Inhibition of apolipoprotein B100 secretion by lipidinduced hepatic endoplasmic reticulum stress in rodents.

Gouni I, Oka K, Etienne J et al (1993) Endotoxin-induced hypertriglyceridemia is mediated by suppression of lipoprotein lipase at a post-transcriptional level. J Lipid Res 34:139–146 140. Kaufmann RL, Matson CF, Beisel WR (1976) Hypertriglyceridemia produced by endotoxin: role of impaired triglyceride disposal mechanisms. J Infect Dis 133:548–555 141. Nogueira AC, Kawabata V, Biselli P et al (2008) Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability.

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