By Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)
ABPP method: advent and evaluation, through Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for traditional Product goal Discovery, by way of Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by way of Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft program of Activity-Based Protein Profiling to the examine of Microbial Pathogenesis, by means of William P. Heal und Edward W. Tate useful research of Protein pursuits via Metabolomic ways, via Yun-Gon Kim und Alan Saghatelian
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To address this, Weerapana et al. developed a strategy to globally characterize cysteine functionality in proteomes with isotopically labeled, ABPP probes . In this approach, named isotopic tandem orthogonal proteolysis–activitybased protein profiling (isoTOP-ABPP), a cysteine-reactive iodoacetamide ABPP probe is applied in two concentrations (high and low) to aliquots of a proteome. After protein labeling, the bound probes are tagged with a biotin attached to an isotopically labeled linker (heavy and light) containing a TEV protease site.